The overall aim of this honors project is the development of quantitative-structure-activity relationships for the sulfonamides; and from this, more potent anticonvulsant drugs. Along these aims, the synthesis and purification of sixteen simple benzenesulfonamides with greatly varying physio-chemical properties was accomplished. In addition, three assay systems measuring the inhibition of carbonic anhydrase by sulfonamides were extensively investigated and evaluated.
Campbell, J. E. (1983). Sulfonamide Inhibition of the Carbonic Anhydrase Catalyzed Hydration of Carbon Dioxide: Toward the Development of Anticonvulsant Drugs (Undergraduate honors thesis, University of Redlands). Retrieved from http://inspire.redlands.edu/cas_honors/122