Department

Chemistry

Publication Year

Fall 1983

Abstract

The overall aim of this honors project is the development of quantitative-structure-activity relationships for the sulfonamides; and from this, more potent anticonvulsant drugs. Along these aims, the synthesis and purification of sixteen simple benzenesulfonamides with greatly varying physio-chemical properties was accomplished. In addition, three assay systems measuring the inhibition of carbonic anhydrase by sulfonamides were extensively investigated and evaluated.

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