Biochemistry and Molecular Biology
Trophic actions of progesterone are, in part, mediated by interaction with the classical intracellular progesterone receptor B isoform (PR-B). Withdrawal of progestational support for pregnancy is integral to the final common pathways for parturition, but the role of progesterone receptor isoforms in the cervix with respect to degradation of extracellular matrix and immune cell immigration at term is not known. To complete cervical remodeling, the findings raise the possibility that PR-A or other receptors may be important for the neuroinflammatory processes that are associated with withdrawal of progesterone, ripening of the cervix, and the mechanism for parturition.
Chhaya, T. (2010). Effects of Progesterone Receptor-B Ablation on Prepartum Remodeling of the Cervix (Undergraduate honors thesis, University of Redlands). Retrieved from http://inspire.redlands.edu/cas_honors/141