Progesterone is a steroid hormone that is responsible in the maintenance of pregnancy and prevention of preterm labor. The withdrawal of progesterone leads to the neuroinflammatory processes associated with cervical ripening and, ultimately, parturition. such actions of progesterone are thought to be exclusively mediated by binding to classical nuclear progesterone receptors (PR) even though progesterone also binds to glucocorticoid receptors (GR). The purpose of this study was to determine whether PR and/or GR regulate neutrophil immigration as part of the inflammatory mechanism that mediates preterm parturition and remodeling of the cervix.
Stutz, K. (2011). The Role of Receptor Activation and the Inflammatory Response in the Maintenance of Pregnancy and Parturition (Undergraduate honors thesis, University of Redlands). Retrieved from http://inspire.redlands.edu/cas_honors/15