Anticonvulsant Drugs, Assay Systems, Sulfonamide Inhibition
The overall aim of this honors project is the development of quantitative-structure-activity relationships for the sulfonamides; and from this, more potent anticonvulsant drugs. Along these aims, the synthesis and purification of sixteen simple benzenesulfonamides with greatly varying physio-chemical properties was accomplished. In addition, three assay systems measuring the inhibition of carbonic anhydrase by sulfonamides were extensively investigated and evaluated.
Department 1 Awarding Honors Status
Campbell, J. E. (1983). Sulfonamide Inhibition of the Carbonic Anhydrase Catalyzed Hydration of Carbon Dioxide: Toward the Development of Anticonvulsant Drugs (Undergraduate honors thesis, University of Redlands). Retrieved from https://inspire.redlands.edu/cas_honors/122
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