Publication Year

1983

Keywords

Anticonvulsant Drugs, Assay Systems, Sulfonamide Inhibition

Disciplines

Organic Chemistry

Abstract

The overall aim of this honors project is the development of quantitative-structure-activity relationships for the sulfonamides; and from this, more potent anticonvulsant drugs. Along these aims, the synthesis and purification of sixteen simple benzenesulfonamides with greatly varying physio-chemical properties was accomplished. In addition, three assay systems measuring the inhibition of carbonic anhydrase by sulfonamides were extensively investigated and evaluated.

Department 1 Awarding Honors Status

Chemistry

Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

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