Title

Computational Analysis of Epidermal Growth Factor Receptor Inhibitors: Anilinoquinazoline Derivatives and 4-(3'-Bromoanilino)-6, 7-dimethoxyquinzoline

Publication Year

1998

Keywords

Computational analysis, receptor inhibitors, anilinoquinazoline

Disciplines

Biochemistry, Biophysics, and Structural Biology | Chemistry | Life Sciences

Abstract

Tyrosine kinase proteins (TKP) and their signaling pathways have been identified as potentials for drug design. In the past decade, many laboratories have been embarked on projects aimed at procuring compounds that inhibit activity of the signaling cascade triggered by TKPs [6]. TKPs can be divided into two families: the receptor tyrosine kinase protein (RTKP) and non-receptor tyrosine kinase protein (NRTKP). This study will concentrate solely on the RTKP family. The RTKP family is made up of tyrosine kinase proteins (TKP) containing large glycosylated, extracellular ligand-binding domain, a hydrophobic single transmembrane region, and a cytoplasmic region which incorporates the kinase catalytic domain. RTKPs can be divided further into four subclasses, each having a conserved kinase catalytic domain. We will deal with the subclass I type of receptors, specifically with the Epidermal Growth Factor Receptor (EGFR) protein.

Department 1 Awarding Honors Status

Biochemistry and Molecular Biology

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