Title

Sulfonamide Inhibitors of Carbonic Anhydrase as Potential Anticonvulsants

Publication Year

1983

Keywords

Chemistry, sulfonamide, antibacterial, bacteria

Disciplines

Chemistry | Physical Sciences and Mathematics

Abstract

In the early 1930's, Mietzch and Klaver were working on the synthesis of various Azo dyes that could be used for dyeing sheep's wool, when it was discovered that some of these dyes appeared to have antibacterial properties. This news spread quickly and started many researchers working with Azo dyes in an attempt to find effective drug treatments for bacterial infections. It was in 1932 that Domagk found that one of these Azo dyes, prontosil, did indeed protect mice from streptococci bacteria. But, much to his surprise, prontosil was not an effective antibacterial agent in vitro. This led to the discovery that the dye prontosil was not the active antibacterial agent, but rather its metabolite, sulfanilamide possessed the antibacterial properties.

Department 1 Awarding Honors Status

Chemistry

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