Title

The Effects of Altitude, Age, and Temperature Stress on Levels of 2, 3-Diphosphoglycerate in the Deer Mouse, (Peromyscus maniculatus)

Publication Year

1978

Keywords

Biology, cells, blood, diophosphoglycerate, deer mouse

Disciplines

Biology | Cell and Developmental Biology

Abstract

The function of 2,3-diphosphoglycerate (2,-DPG) was unknown until 1968 when Benesch and Benesch reported that the presence of phosphorylated compounds, such as 2,3-DPG or ATP, would produce a concomitant reduction in the oxygen affinity of hemoglobin (Hb) solutions. Human red blood cells typically contain 5 X 10-3 molar 2,3-DPG, or approximately one mole of 2,3-DPG per mole of hemoglobin, whereas other mammalian cell types contain only trace amounts. 2,3-DPG is now known to affect the oxygen transport function of hemoglobin. It's thought to operate by binding to the deoxygenated hemoglobin molecule in competition with oxygen. Higher levels of 2,3-DPG relative to hemoglobin concentration act to shift the oxygen dissociation curve tot he right. Blood displaying a right-shifted oxygen dissociation curve will deliver greater volumes of oxygen to the capillary beds. The 2,3-DPG mediated increase in oxygen transport is found in cases of anemia of various etiologies and in mammals exposed to the hypoxia of high altitudes.

*This thesis was presented for Honors to both the Dept. of Biology at the University of Redlands and the Dept. of Biology at the University of California, Riverside.

Department 1 Awarding Honors Status

Biology

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