Title

The Effect of Alloxan Induced Diabetes on Cholesterol and Blood Pressure in Rats

Publication Year

1973

Keywords

diabetes, blood pressure, alloxan, cholesterol, biology

Disciplines

Biology | Cardiology | Endocrinology, Diabetes, and Metabolism | Medicine and Health Sciences

Abstract

Vascular disease occurs frequently among diabetics. Indeed, it is considered to be the major complication of diabetes mellitus. A number of people have suggested that the high occurrence of vascular disorder among diabetics may be related to a failure to maintain normal blood sugar levels. Thus, many studies have been conducted to assess the relationship between the degree of control by human diabetics and the frequency and severity of vascular complications. According to Knowles, over 300 publicized opinions have appeared since 1930. However, the results are variable and controversial. Some evidence suggests that complications in diabetic patients who have poor control by conventional standards are not significantly different from those patients who exercise good control. However, the view firmly held by many physicians throughout the world is that strict control postpones vascular complications. The clinical management of a majority of diabetics is based on maintaining good control, with sugar free urine and normal blood sugar. Some investigators feel that even minor deviations from normal blood sugar may increase the risk of cardiovascular disease, even at blood glucose levels which are not elevated sufficiently to give a positive diagnosis of diabetes.

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