A Study of the Mechanism and Synthesis of N-2-hydroxyethl-DL-Methionine and N-2-chloroethyl Amino Acids and their Effects on Tumor Cell Growth, in vitro
biology, tumor cell growth, amino acids, cancer cells, methods of synthesis, chemotherapeutics
Biology | Cancer Biology | Cell and Developmental Biology
In the field of chemotherapeutics, the effects of various chemicals on cancerous tissue are being studied. These prospective anti-cancer drugs, some of which are labeled as "alkylating agents," include five chief types of cytotoxic compounds. These include ethylenimines, sulfonic esters, epoxides, N-alkyl-N-nitroso compounds, and both sulfur and nitrogen mustards. These agents are chemically active compounds that react quickly and are rapidly metabolized. They are called alkylating agents of their ability to react with, or alkylate, a number of chemical groupings, many of which are of vital importance in cell functions.
Ellis, D. A. (1972). A Study of the Mechanism and Synthesis of N-2-hydroxyethl-DL-Methionine and N-2-chloroethyl Amino Acids and their Effects on Tumor Cell Growth, in vitro (Undergraduate honors thesis, University of Redlands). Retrieved from https://inspire.redlands.edu/cas_honors/423