Publication Year

2011

Keywords

DNA, Anticancer therapies, synthesis, ruthenium

Disciplines

Cancer Biology | Chemistry | Inorganic Chemistry | Oncology

Abstract

Side effects associated with platinum-based anticancer therapies have resulted in the search for novel nonplatinum-based metal species. Among the different metal complexes generating interest, rutheniumII complexes have shown great potential as anticancer agents. A series of mixed ligand ruthenium complexes with he formula cis-[Ru(X)(HPB)(OH2)], where X corresponds to either (1) Terpy = 2,2':6',2"-terpyridine; (2) Pheterpy = 4' -Phenyl-2,2':6',2"-terpyridine or (3) Tterpy = 4'-Tolyl-2,2':6',2"-terpyridine, and HPB = 2-(2' -hydroxyphenyl)-benozoxazole, have been synthesized and structurally characterized. The DNA binding of the rutheniumII complexes has been studied using several physical methods including absorption spectroscopy and competitive binding displacement assays. The abilit of the complexes to unwind and / or untwist DNA has also been studied using supercoiled pUC18 DNA.

Department 1 Awarding Honors Status

Chemistry

Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

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