Chemistry, Ortho Lithiation, benzamides, steric, molecular structure, chemical reaction
Chemistry | Organic Chemistry | Physical Sciences and Mathematics
Steric effects is the term used to describe the attractive or repulsive forces which are exerted between molecular groups that are not directly bonded to one another. Such groups may be bonded to the same molecule (intramolecular effect) or to different molecules (intermolecular effect). As an example of intramolecular steric effects, consider two of the possible conformations of n-butane [...]. N-butane is in its most stable form when the terminal methyl groups are farthest apart (the anti conformation) and repulsion between these methyl groups is thus minimized. In the highly unstable eclipsed conformation, however, steric effects are at a maximum. Thus steric repulsion between the methyl groups on the ends of the n-butane molecule are seen to influence the stability of the conformers. The magnitude of any such steric interactions will be a function of the spatial requirements, bulkiness, or effective size of the substitutents involved.
Department 1 Awarding Honors Status
Frana, L. P. (1986). Quantification of Steric Bulk: The Ortho-Lithiation of Benzamides (Undergraduate honors thesis, University of Redlands). Retrieved from https://inspire.redlands.edu/cas_honors/614