Document Title
Rebuttal of “Flawed Experimental Design Reveals the Need for Guidelines Requiring Appropriate Positive Controls in Endocrine Disruption Research” by vom Saal
Department/School
Biology
Abstract
In response to the letter to Toxicological Sciences by Vom Saal (2010) that provided criticisms of our recent paper, we have prepared a categorical rebuttal.
In this rebuttal, we describe
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That the developmental effects of the potent environment estrogen ethinyl estradiol (EE2) address important agency research needs and that EE2 is not just a “positive control.”
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Why the Long Evans (LE) rat and several other rat strains are excellent animal models for the study of the potential adverse effects of xenoestrogens.
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Why the argument that LE rats and other rat strains are “insensitive strains” is not consistent with
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(a) the pharmacological and toxicological data showing that humans and these rat strains display similar sensitivities to EE2 and
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(b) the cellular and molecular biology of the action of estrogens on different target tissues
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How the effects of leaching of bisphenol A (BPA) from polycarbonate cages have been grossly exaggerated.
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That governmental regulatory agencies have concluded that studies like ours (Ryan et al., 2010) are useful for risk assessment, whereas many of the “positive” low-dose studies were “inadequate” or the results have not been replicated.
Document Type
Article
Publication Title
Toxicological Sciences
Publication Date
6-2010
Volume
115
Issue
2
Pages
614-620
Digital Object Identifier (DOI)
10.1093/toxsci/kfq073
PubMed ID (PMID)
29910598