Document Title

Rebuttal of “Flawed Experimental Design Reveals the Need for Guidelines Requiring Appropriate Positive Controls in Endocrine Disruption Research” by vom Saal

Department/School

Biology

Abstract

In response to the letter to Toxicological Sciences by Vom Saal (2010) that provided criticisms of our recent paper, we have prepared a categorical rebuttal.

In this rebuttal, we describe

  • That the developmental effects of the potent environment estrogen ethinyl estradiol (EE2) address important agency research needs and that EE2 is not just a “positive control.”

  • Why the Long Evans (LE) rat and several other rat strains are excellent animal models for the study of the potential adverse effects of xenoestrogens.

  • Why the argument that LE rats and other rat strains are “insensitive strains” is not consistent with

    • (a) the pharmacological and toxicological data showing that humans and these rat strains display similar sensitivities to EE2 and

    • (b) the cellular and molecular biology of the action of estrogens on different target tissues

  • How the effects of leaching of bisphenol A (BPA) from polycarbonate cages have been grossly exaggerated.

  • That governmental regulatory agencies have concluded that studies like ours (Ryan et al., 2010) are useful for risk assessment, whereas many of the “positive” low-dose studies were “inadequate” or the results have not been replicated.

Document Type

Article

Publication Title

Toxicological Sciences

Publication Date

6-2010

Volume

115

Issue

2

Pages

614-620

Digital Object Identifier (DOI)

10.1093/toxsci/kfq073

PubMed ID (PMID)

29910598

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